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Yet, with close to 40% of users reporting this as the side effect leading to discontinuation of therapy, it is a crucial factor to address [6]

3.2.1 Epigenetic drug combination with chemotherapy to overcome resistance Epigenetic drugs combined with chemotherapy have shown promising results in overcoming treatment resistance in AML by reactivating silenced tumor suppressor genes and enhancing the sensitivity of leukemic cells to cytotoxic agents